Case 05

Case contributed by: Dr. Asif Loya, M.D., FIAC, FRCP (Edin), FCPS,
Diplomate American Board of Pathology
CONSULTANT PATHOLOGIST AND
MEDICAL DIRECTOR
Shaukat Khanum Memorial Cancer Hospital And Research Centre

Case Description

A few details

History:

17 years old female presented with vision loss and nausea vomiting for 1 month. On radiology there is an intraventricular space occupying lesion.

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Case 05

Case Description

Fig 1

Fig 2

Fig 3 GFAP

Fig 4 H3G34

Fig 5 H3K27me3

Fig 6 Histone3

Fig 7 IDH

Fig 8 Ki67

Fig 9 Olig2

Fig 10 Synaptophysin

The characteristic immunohistochemical finding in H3K27-altered diffuse midline glioma is: